A dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilis.
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ABSTRACT:
SUBMITTER: Pedrolli DB
PROVIDER: S-EPMC4653141 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
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A dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilis.
Pedrolli Danielle Biscaro DB Kühm Christian C Sévin Daniel C DC Vockenhuber Michael P MP Sauer Uwe U Suess Beatrix B Mack Matthias M
Proceedings of the National Academy of Sciences of the United States of America 20151022 45
Flavin mononucleotide (FMN) riboswitches are genetic elements, which in many bacteria control genes responsible for biosynthesis and/or transport of riboflavin (rib genes). Cytoplasmic riboflavin is rapidly and almost completely converted to FMN by flavokinases. When cytoplasmic levels of FMN are sufficient ("high levels"), FMN binding to FMN riboswitches leads to a reduction of rib gene expression. We report here that the protein RibR counteracts the FMN-induced "turn-off" activities of both FM ...[more]
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