Ontology highlight
ABSTRACT:
SUBMITTER: Jiang B
PROVIDER: S-EPMC4653826 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Jiang Bin B Jen Michele M Perrin Louisiane L Wertheim Jason A JA Ameer Guillermo A GA
Stem cells and development 20151028 23
Endothelial cells (ECs) that are differentiated from induced pluripotent stem cells (iPSCs) can be used in establishing disease models for personalized drug discovery or developing patient-specific vascularized tissues or organoids. However, a number of technical challenges are often associated with iPSC-ECs in culture, including instability of the endothelial phenotype and limited cell proliferative capacity over time. Early senescence is believed to be the primary mechanism underlying these li ...[more]