Ontology highlight
ABSTRACT:
SUBMITTER: Singh SK
PROVIDER: S-EPMC4654943 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Singh Sanjay K SK Marisetty Anantha A Sathyan Pratheesh P Kagalwala Mohamedi M Zhao Zhaoyang Z Majumder Sadhan S
Stem cell research 20150702 2
Our previous studies have shown that the regulatory network that maintains pluripotency in mouse embryonic stem cells (mESCs) is regulated in a context-dependent manner and can be modulated, at least in part, by re-calibration of an intracellular network of pluripotency factors as well as cues arising from the extracellular matrix. The transcriptional repressor REST represses miR-21 and, thus, regulates self-renewal in E14Tg2a.4 mESCs cultured in the absence of mouse embryonic fibroblast feeder ...[more]