Ontology highlight
ABSTRACT:
SUBMITTER: Benitez AA
PROVIDER: S-EPMC4654977 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Benitez Asiel Arturo AA Spanko Laura Adrienne LA Bouhaddou Mehdi M Sachs David D tenOever Benjamin Robert BR
Cell reports 20151105 7
Although the intrinsic antiviral cell defenses of many kingdoms utilize pathogen-specific small RNAs, the antiviral response of chordates is primarily protein based and not uniquely tailored to the incoming microbe. In an effort to explain this evolutionary bifurcation, we determined whether antiviral RNAi was sufficient to replace the protein-based type I interferon (IFN-I) system of mammals. To this end, we recreated an RNAi-like response in mammals and determined its effectiveness to combat i ...[more]