Ontology highlight
ABSTRACT:
SUBMITTER: Adiliaghdam F
PROVIDER: S-EPMC7039342 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Adiliaghdam Fatemeh F Basavappa Megha M Saunders Tahnee L TL Harjanto Dewi D Prior John T JT Cronkite D Alexander DA Papavasiliou Nina N Jeffrey Kate L KL
Cell reports 20200201 6
While interferon (IFN) responses are critical for mammalian antiviral defense, induction of antiviral RNA interference (RNAi) is evident. To date, individual functions of the mammalian RNAi and micro RNA (miRNA) effector proteins Argonautes 1-4 (AGO1-AGO4) during virus infection remain undetermined. AGO2 was recently implicated in mammalian antiviral defense, so we examined antiviral activity of AGO1, AGO3, or AGO4 in IFN-competent immune cells. Only AGO4-deficient cells are hyper-susceptible to ...[more]