Ontology highlight
ABSTRACT:
SUBMITTER: Legoux FP
PROVIDER: S-EPMC4654997 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Legoux Francois P FP Lim Jong-Baeck JB Cauley Andrew W AW Dikiy Stanislav S Ertelt James J Mariani Thomas J TJ Sparwasser Tim T Way Sing Sing SS Moon James J JJ
Immunity 20151110 5
Deletion of self-antigen-specific T cells during thymic development provides protection from autoimmunity. However, it is unclear how efficiently this occurs for tissue-restricted self antigens, or how immune tolerance is maintained for self-antigen-specific T cells that routinely escape deletion. Here we show that endogenous CD4+ T cells with specificity for a set of tissue-restricted self antigens were not deleted at all. For pancreatic self antigen, this resulted in an absence of steady-state ...[more]