Ontology highlight
ABSTRACT:
SUBMITTER: Kazak L
PROVIDER: S-EPMC4656041 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Kazak Lawrence L Chouchani Edward T ET Jedrychowski Mark P MP Erickson Brian K BK Shinoda Kosaku K Cohen Paul P Vetrivelan Ramalingam R Lu Gina Z GZ Laznik-Bogoslavski Dina D Hasenfuss Sebastian C SC Kajimura Shingo S Gygi Steve P SP Spiegelman Bruce M BM
Cell 20151022 3
Thermogenic brown and beige adipose tissues dissipate chemical energy as heat, and their thermogenic activities can combat obesity and diabetes. Herein the functional adaptations to cold of brown and beige adipose depots are examined using quantitative mitochondrial proteomics. We identify arginine/creatine metabolism as a beige adipose signature and demonstrate that creatine enhances respiration in beige-fat mitochondria when ADP is limiting. In murine beige fat, cold exposure stimulates mitoch ...[more]