Ontology highlight
ABSTRACT:
SUBMITTER: Wakatsuki S
PROVIDER: S-EPMC4657170 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Wakatsuki Shuji S Furuno Akiko A Ohshima Makiko M Araki Toshiyuki T
The Journal of cell biology 20151116 4
Oxidative stress is a well-known inducer of neuronal apoptosis and axonal degeneration. We previously showed that the E3 ubiquitin ligase ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B activation. We now demonstrate that oxidative stress serves as an activator of the ubiquitin ligase activity of ZNRF1 by inducing epidermal growth factor receptor (EGFR)-mediated phosphorylation at the 103rd tyrosine residue and that the up-regulation of ZNRF1 activity by oxidative stress l ...[more]