Dataset Information

Investigating white matter perfusion using optimal sampling strategy arterial spin labeling at 7 Tesla.

ABSTRACT:

Purpose

Cerebral blood flow (CBF) is an informative physiological marker for tissue health. Arterial spin labeling (ASL) is a noninvasive MRI method of measuring this parameter, but it has proven difficult to measure white matter (WM) CBF due to low intrinsic contrast-to-noise ratio compared with gray matter (GM). Here we combine ultra-high field and optimal sampling strategy (OSS) ASL to investigate WM CBF in reasonable scan times.

Methods

A FAIR-based ASL sequence at 7T was combined with a real-time-feedback OSS technique, to iteratively improve post-label image acquisition times (TIs) on a tissue- and subject-specific basis to obtain WM CBF quantification.

Results

It was found 77% of WM voxels gave a reasonable CBF fit. Averaged WM CBF for these voxels was found to be 16.3 ± 1.5 mL/100 g/min (discarding partial-volumed voxels). The generated TI schedule was also significantly different when altering the OSS weighted-tissue-mask, favoring longer TIs in WM.

Conclusion

WM CBF could be reasonably quantified in over 75% of identified voxels, from a total preparation and scan time of 15 min. OSS results suggest longer TIs should be used versus general GM ASL settings; this may become more important in WM disease studies.

SUBMITTER: Gardener AG

PROVIDER: S-EPMC4657501 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Publications

Investigating white matter perfusion using optimal sampling strategy arterial spin labeling at 7 Tesla.

Gardener Alexander G AG Jezzard Peter P

Magnetic resonance in medicine 20140620 6

<h4>Purpose</h4>Cerebral blood flow (CBF) is an informative physiological marker for tissue health. Arterial spin labeling (ASL) is a noninvasive MRI method of measuring this parameter, but it has proven difficult to measure white matter (WM) CBF due to low intrinsic contrast-to-noise ratio compared with gray matter (GM). Here we combine ultra-high field and optimal sampling strategy (OSS) ASL to investigate WM CBF in reasonable scan times.<h4>Methods</h4>A FAIR-based ASL sequence at 7T was comb ...[more]

PMID: 24954898

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Project description:BackgroundArterial spin labeling (ASL) perfusion-weighted imaging (PWI) by magnetic resonance imaging (MRI) has been shown to be useful for identifying asphyxiated newborns at risk of developing brain injury, whether or not therapeutic hypothermia was administered. However, this technique has been only rarely used in newborns until now, because of the challenges to obtain sufficient signal-to-noise ratio (SNR) and spatial resolution in newborns.ObjectiveTo compare two methods of ASL-PWI (i.e., single inversion-time pulsed arterial spin labeling [single TI PASL], and pseudo-continuous arterial spin labeling [pCASL]) to assess brain perfusion in asphyxiated newborns treated with therapeutic hypothermia and in healthy newborns.Design/methodsWe conducted a prospective cohort study of term asphyxiated newborns meeting the criteria for therapeutic hypothermia; four additional healthy term newborns were also included as controls. Each of the enrolled newborns was scanned at least once during the first month of life. Each MRI scan included conventional anatomical imaging, as well as PASL and pCASL PWI-MRI. Control and labeled images were registered separately to reduce the effect of motion artifacts. For each scan, the axial slice at the level of the basal ganglia was used for comparisons. Each scan was scored for its image quality. Quantification of whole-slice cerebral blood flow (CBF) was done afterwards using previously described formulas.ResultsA total number of 61 concomitant PASL and pCASL scans were obtained in nineteen asphyxiated newborns treated with therapeutic hypothermia and four healthy newborns. After discarding the scans with very poor image quality, 75% (46/61) remained for comparison between the two ASL methods. pCASL images presented a significantly superior image quality score compared to PASL images (p < 0.0001). Strong correlation was found between the CBF measured by PASL and pCASL (r = 0.61, p < 0.0001).ConclusionThis study demonstrates that both ASL methods are feasible to assess brain perfusion in healthy and sick newborns. However, pCASL might be a better choice over PASL in newborns, as pCASL perfusion maps had a superior image quality that allowed a more detailed identification of the different brain structures.

Dataset Information

Investigating white matter perfusion using optimal sampling strategy arterial spin labeling at 7 Tesla.

Purpose

Methods

Results

Conclusion

Publications

Investigating white matter perfusion using optimal sampling strategy arterial spin labeling at 7 Tesla.

Similar Datasets

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