Dataset Information

Pharmacology and Clinical Drug Candidates in Redox Medicine.

ABSTRACT: Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant molecules, has been unsuccessful.An alternative emerging approach is to target the enzymatic sources of disease-relevant oxidative stress. Several such enzymes and isoforms have been identified and linked to different pathologies. For some targets, the respective pharmacology is quite advanced, that is, up to late-stage clinical development or even on the market; for others, drugs are already in clinical use, although not for indications based on oxidative stress, and repurposing seems to be a viable option.For all other targets, reliable preclinical validation and drug ability are key factors for any translation into the clinic. In this study, specific pharmacological agents with optimal pharmacokinetic profiles are still lacking. Moreover, these enzymes also serve largely unknown physiological functions and their inhibition may lead to unwanted side effects.The current promising data based on new targets, drugs, and drug repurposing are mainly a result of academic efforts. With the availability of optimized compounds and coordinated efforts from academia and industry scientists, unambiguous validation and translation into proof-of-principle studies seem achievable in the very near future, possibly leading towards a new era of redox medicine.

SUBMITTER: Dao VT

PROVIDER: S-EPMC4657508 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Pharmacology and Clinical Drug Candidates in Redox Medicine.

Dao V Thao-Vi VT Casas Ana I AI Maghzal Ghassan J GJ Seredenina Tamara T Kaludercic Nina N Robledinos-Anton Natalia N Di Lisa Fabio F Stocker Roland R Ghezzi Pietro P Jaquet Vincent V Cuadrado Antonio A Cuadrado Antonio A Schmidt Harald H H W HH

Antioxidants & redox signaling 20151106 14

<h4>Significance</h4>Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant molecules, has been unsuccessful.<h4>Recent advances</h4>An alternative emerging approach is to target the enzymatic sources of disease-relevant oxidative stress. Several such enzymes and isoforms have been identified and linked to different p ...[more]

PMID: 26415051

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Dataset Information

Pharmacology and Clinical Drug Candidates in Redox Medicine.

Publications

Pharmacology and Clinical Drug Candidates in Redox Medicine.

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