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Anti-SARS-CoV-2 Repurposing Drug Database: Clinical Pharmacology Considerations.


ABSTRACT: A critical step to evaluate the potential in vivo antiviral activity of a drug is to connect the in vivo exposure to its in vitro antiviral activity. The Anti-SARS-CoV-2 Repurposing Drug Database is a database that includes both in vitro anti-SARS-CoV-2 activity and in vivo pharmacokinetic data to facilitate the extrapolation from in vitro antiviral activity to potential in vivo antiviral activity for a large set of drugs/compounds. In addition to serving as a data source for in vitro anti-SARS-CoV-2 activity and in vivo pharmacokinetic information, the database is also a calculation tool that can be used to compare the in vitro antiviral activity with in vivo drug exposure to identify potential anti-SARS-CoV-2 drugs. Continuous development and expansion are feasible with the public availability of this database.

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8420371 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Anti-SARS-CoV-2 Repurposing Drug Database: Clinical Pharmacology Considerations.

Zhang Xinyuan X   Yang Yuching Y   Grimstein Manuela M   Liu Guansheng G   Kitabi Eliford E   Fan Jianghong J   Wang Ying-Hong YH   Earp Justin J   Weaver James L JL   Zhu Hao H   Liu Jiang J   Reynolds Kellie S KS   Huang Shiew-Mei SM   Wang Yaning Y  

CPT: pharmacometrics & systems pharmacology 20210801 9


A critical step to evaluate the potential in vivo antiviral activity of a drug is to connect the in vivo exposure to its in vitro antiviral activity. The Anti-SARS-CoV-2 Repurposing Drug Database is a database that includes both in vitro anti-SARS-CoV-2 activity and in vivo pharmacokinetic data to facilitate the extrapolation from in vitro antiviral activity to potential in vivo antiviral activity for a large set of drugs/compounds. In addition to serving as a data source for in vitro anti-SARS-  ...[more]

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