Ontology highlight
ABSTRACT:
SUBMITTER: Pisco AO
PROVIDER: S-EPMC4657953 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Pisco Angela Oliveira AO Brock Amy A Zhou Joseph J Moor Andreas A Mojtahedi Mitra M Jackson Dean D Huang Sui S
Nature communications 20130101
The development of drug resistance, the prime cause of failure in cancer therapy, is commonly explained by the selection of resistant mutant cancer cells. However, dynamic non-genetic heterogeneity of clonal cell populations continuously produces metastable phenotypic variants (persisters), some of which represent stem-like states that confer resistance. Even without genetic mutations, Darwinian selection can expand these resistant variants, which would explain the invariably rapid emergence of ...[more]