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Double-Layer Magnetic Nanoparticle-Embedded Silica Particles for Efficient Bio-Separation.

ABSTRACT: Superparamagnetic Fe3O4 nanoparticles (NPs) based nanomaterials have been exploited in various biotechnology fields including biomolecule separation. However, slow accumulation of Fe3O4 NPs by magnets may limit broad applications of Fe3O4 NP-based nanomaterials. In this study, we report fabrication of Fe3O4 NPs double-layered silica nanoparticles (DL MNPs) with a silica core and highly packed Fe3O4 NPs layers. The DL MNPs had a superparamagnetic property and efficient accumulation kinetics under an external magnetic field. Moreover, the magnetic field-exposed DL MNPs show quantitative accumulation, whereas Fe3O4 NPs single-layered silica nanoparticles (SL MNPs) and silica-coated Fe3O4 NPs produced a saturated plateau under full recovery of the NPs. DL MNPs are promising nanomaterials with great potential to separate and analyze biomolecules.

SUBMITTER: Kyeong S

PROVIDER: S-EPMC4658053 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Double-Layer Magnetic Nanoparticle-Embedded Silica Particles for Efficient Bio-Separation.

Kyeong San S Jeong Cheolhwan C Kang Homan H Cho Hong-Jun HJ Park Sung-Jun SJ Yang Jin-Kyoung JK Kim Sehoon S Kim Hyung-Mo HM Jun Bong-Hyun BH Lee Yoon-Sik YS

PloS one 20151124 11

Superparamagnetic Fe3O4 nanoparticles (NPs) based nanomaterials have been exploited in various biotechnology fields including biomolecule separation. However, slow accumulation of Fe3O4 NPs by magnets may limit broad applications of Fe3O4 NP-based nanomaterials. In this study, we report fabrication of Fe3O4 NPs double-layered silica nanoparticles (DL MNPs) with a silica core and highly packed Fe3O4 NPs layers. The DL MNPs had a superparamagnetic property and efficient accumulation kinetics under ...[more]

PMID: 26599084

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