First identification of an IMI-1 carbapenemase-producing colistin-resistant Enterobacter cloacae in China.

ABSTRACT:

Background

Carbapenem resistance among the Enterobacteriaceae is a serious healthcare challenge. bla IMI is a carbapenemase gene mediating resistance to carbapenems but has not been commonly found. A bla IMI-carrying Enterobacter cloacae, which was also resistant to colistin, is reported here.

Findings

E. cloacae strain WCHECl-1060 was recovered from a blood sample of a leukemia patient, who was not previously exposed to colistin. Strain WCHECl-1060 belongs to a new sequence type, ST410, and was resistant to carbapenems and colistin but was susceptible to third-generation cephalosporins. A new allelic variant of bla IMI-1, which has two silent mutations compared to the original bla IMI-1 variant, was found in strain WCHECl-1060. Conjugation and transformation experiments fai

SUBMITTER: Huang L 

PROVIDER: S-EPMC4658791 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature