Recent functional insights into the role of (p)ppGpp in bacterial physiology.
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ABSTRACT:
SUBMITTER: Hauryliuk V
PROVIDER: S-EPMC4659695 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Publications
Recent functional insights into the role of (p)ppGpp in bacterial physiology.
Hauryliuk Vasili V Atkinson Gemma C GC Murakami Katsuhiko S KS Tenson Tanel T Gerdes Kenn K
Nature reviews. Microbiology 20150408 5
The alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively referred to as (p)ppGpp) are involved in regulating growth and several different stress responses in bacteria. In recent years, substantial progress has been made in our understanding of the molecular mechanisms of (p)ppGpp metabolism and (p)ppGpp-mediated regulation. In this Review, we summarize these recent insights, with a focus on the molecular mechanisms governing the activity of the RelA/SpoT homologue (RSH) ...[more]
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