Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer.
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ABSTRACT:
SUBMITTER: Murtaza M
PROVIDER: S-EPMC4659935 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Publications
Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer.
Murtaza Muhammed M Dawson Sarah-Jane SJ Pogrebniak Katherine K Rueda Oscar M OM Provenzano Elena E Grant John J Chin Suet-Feung SF Tsui Dana W Y DWY Marass Francesco F Gale Davina D Ali H Raza HR Shah Pankti P Contente-Cuomo Tania T Farahani Hossein H Shumansky Karey K Kingsbury Zoya Z Humphray Sean S Bentley David D Shah Sohrab P SP Wallis Matthew M Rosenfeld Nitzan N Caldas Carlos C
Nature communications 20151104
Circulating tumour DNA analysis can be used to track tumour burden and analyse cancer genomes non-invasively but the extent to which it represents metastatic heterogeneity is unknown. Here we follow a patient with metastatic ER-positive and HER2-positive breast cancer receiving two lines of targeted therapy over 3 years. We characterize genomic architecture and infer clonal evolution in eight tumour biopsies and nine plasma samples collected over 1,193 days of clinical follow-up using exome and ...[more]
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