Ontology highlight
ABSTRACT:
SUBMITTER: Shekhar S
PROVIDER: S-EPMC4660058 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Shekhar Shashank S Kerleau Mikael M Kühn Sonja S Pernier Julien J Romet-Lemonne Guillaume G Jégou Antoine A Carlier Marie-France MF
Nature communications 20151113
Proteins targeting actin filament barbed ends play a pivotal role in motile processes. While formins enhance filament assembly, capping protein (CP) blocks polymerization. On their own, they both bind barbed ends with high affinity and very slow dissociation. Their barbed-end binding is thought to be mutually exclusive. CP has recently been shown to be present in filopodia and controls their morphology and dynamics. Here we explore how CP and formins may functionally coregulate filament barbed-e ...[more]