Ontology highlight
ABSTRACT:
SUBMITTER: Shim J
PROVIDER: S-EPMC4660205 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Nature communications 20151116
The ability to detect toxic compounds in foods is essential for animal survival. However, the minimal subunit composition of gustatory receptors required for sensing aversive chemicals in Drosophila is unknown. Here we report that three gustatory receptors, GR8a, GR66a and GR98b function together in the detection of L-canavanine, a plant-derived insecticide. Ectopic co-expression of Gr8a and Gr98b in Gr66a-expressing, bitter-sensing gustatory receptor neurons (GRNs) confers responsiveness to L-c ...[more]