Ontology highlight
ABSTRACT:
SUBMITTER: Aschar-Sobbi R
PROVIDER: S-EPMC4661059 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Aschar-Sobbi Roozbeh R Izaddoustdar Farzad F Korogyi Adam S AS Wang Qiongling Q Farman Gerrie P GP Yang FengHua F Yang Wallace W Dorian David D Simpson Jeremy A JA Tuomi Jari M JM Jones Douglas L DL Nanthakumar Kumaraswamy K Cox Brian B Wehrens Xander H T XH Dorian Paul P Backx Peter H PH
Nature communications 20150119
Atrial fibrillation (AF) is the most common supraventricular arrhythmia that, for unknown reasons, is linked to intense endurance exercise. Our studies reveal that 6 weeks of swimming or treadmill exercise improves heart pump function and reduces heart-rates. Exercise also increases vulnerability to AF in association with inflammation, fibrosis, increased vagal tone, slowed conduction velocity, prolonged cardiomyocyte action potentials and RyR2 phosphorylation (CamKII-dependent S2814) in the atr ...[more]