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Muscle Power Is an Independent Determinant of Pain and Quality of Life in Knee Osteoarthritis.

ABSTRACT: This study examined the relationships between leg muscle strength, power, and perceived disease severity in subjects with knee osteoarthritis (OA) in order to determine whether dynamic leg extensor muscle power would be associated with pain and quality of life in knee OA.Baseline data on 190 subjects with knee OA (mean?±?SD age 60.2?±?10.4 years, body mass index 32.7?±?7.2 kg/m(2) ) were obtained from a randomized controlled trial. Knee pain was measured using the Western Ontario and McMaster Universities Osteoarthritis Index, and health-related quality of life was assessed using the Short Form 36 (SF-36). One-repetition maximum (1RM) strength was assessed using the bilateral leg press, and peak muscle power was measured during 5 maximum voluntary velocity repetitions at 40% and 70% of 1RM.In univariate analysis, greater muscle power was significantly associated with pain (r?=?-0.17, P < 0.02) and also significantly and positively associated with SF-36 physical component summary (PCS) scores (r?=?0.16, P < 0.05). After adjustment for multiple covariates, muscle power was a significant independent predictor of pain (P ? 0.05) and PCS scores (P ? 0.04). However, muscle strength was not an independent determinant of pain or quality of life (P ? 0.06).Muscle power is an independent determinant of pain and quality of life in knee OA. Compared to strength, muscle power may be a more clinically important measure of muscle function within this population. New trials to systematically examine the impact of muscle power training interventions on disease severity in knee OA are particularly warranted.

SUBMITTER: Reid KF

PROVIDER: S-EPMC4661064 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Muscle Power Is an Independent Determinant of Pain and Quality of Life in Knee Osteoarthritis.

Reid Kieran F KF Price Lori Lyn LL Harvey William F WF Driban Jeffrey B JB Hau Cynthia C Fielding Roger A RA Wang Chenchen C

Arthritis & rheumatology (Hoboken, N.J.) 20151201 12

<h4>Objective</h4>This study examined the relationships between leg muscle strength, power, and perceived disease severity in subjects with knee osteoarthritis (OA) in order to determine whether dynamic leg extensor muscle power would be associated with pain and quality of life in knee OA.<h4>Methods</h4>Baseline data on 190 subjects with knee OA (mean ± SD age 60.2 ± 10.4 years, body mass index 32.7 ± 7.2 kg/m(2) ) were obtained from a randomized controlled trial. Knee pain was measured using t ...[more]

PMID: 26315282

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Project description:OBJECTIVE:To determine whether thigh muscle strength predicts the risk of undergoing knee replacement surgery, independent of radiographic severity of osteoarthritis and pain. METHODS:Participants in the Osteoarthritis Initiative study who had received a knee replacement between the 12-month and 60-month follow-up visits (cases) were each matched with 1 control subject (who did not receive a knee replacement over 60 months) for age, sex, height, body mass index, baseline radiographic stage, and location of joint space narrowing. Isometric knee extensor and flexor strength was recorded biennially. The strength examination prior to knee replacement (?2 years) was termed time 0, that 2 years prior to time 0 was termed time -2, and that 4 years prior to time 0 was termed time -4. Muscle strength in patients and controls was compared using paired t-tests and conditional logistic regression analysis adjusted for pain. RESULTS:One hundred thirty-six participants (60% women, mean?±?SD age 65?±?9 years, body mass index 29?±?4 kg/m(2) ) received a knee replacement during follow-up, had strength data for at least time 0, and had a matched control. Knee extensor strength at time 0 (primary outcome measure) was significantly lower in female patients compared with controls (P < 0.001, pain-adjusted odds ratio [ORadj ] 1.72, 95% confidence interval 1.16-2.56), but no significant difference was observed in men. Results were similar for knee flexor strength at time 0 and for longitudinal change in extensor and flexor strength between time -2 and time 0. Thigh muscle strength at time -2 or time -4, or change between time -4 and time -2, did not predict the risk of undergoing knee replacement surgery in men or women. CONCLUSION:Thigh muscle strength predicted the risk of undergoing knee replacement surgery in women, but not in men. The results of this study may identify a window during which the risk of undergoing knee replacement surgery in women can be modified.

Dataset Information

Muscle Power Is an Independent Determinant of Pain and Quality of Life in Knee Osteoarthritis.

Publications

Muscle Power Is an Independent Determinant of Pain and Quality of Life in Knee Osteoarthritis.

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