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Dietary inflammatory index is associated with pain intensity and some components of quality of life in patients with knee osteoarthritis.

ABSTRACT: OBJECTIVES:We aim to measure dietary inflammatory index (DII) and its association with functional status, pain intensity and quality of life (QOL) in patients with knee osteoarthritis (KOA). Dietary information from 220 qualified patients with KOA was collected by a 168-item food frequency questionnaire. The functional status, pain intensity and QOL were evaluated by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire, Visual Analogue Scale (VAS) and SF36 questionnaire respectively. RESULTS:Linear regression analysis showed that the DII was significantly associated with VAS (p?=?0.040; ??=?0.151), and physical function (p?=?0.039; ??=?-?0.184), emotional wellbeing (p?=?0.048; ??=?-?0.158) and pain (p?=?0.020; ??=?0.161) scales and physical health (p?=?0.047; ??=?0.110) subscale of QOL after adjusting for age, sex, body mass index, and physical activity. There was no significant differences concerning WOMAC across the DII tertiles with and without adjustment to probable confounders (Ptrend?=?0.091 and 0.181, respectively). After adjustment, a significantly increased severe pain odds was observed in the highest tertile of DII score in comparison with the lowest tertile (OR tertile 3 vs. 1?=?1.55, 95% CI 1.04-2.31; Ptrend?=?0.04).

SUBMITTER: Toopchizadeh V

PROVIDER: S-EPMC7507718 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Dietary inflammatory index is associated with pain intensity and some components of quality of life in patients with knee osteoarthritis.

Toopchizadeh Vahideh V Dolatkhah Neda N Aghamohammadi Dawood D Rasouli Mahrokh M Hashemian Maryam M

BMC research notes 20200921 1

<h4>Objectives</h4>We aim to measure dietary inflammatory index (DII) and its association with functional status, pain intensity and quality of life (QOL) in patients with knee osteoarthritis (KOA). Dietary information from 220 qualified patients with KOA was collected by a 168-item food frequency questionnaire. The functional status, pain intensity and QOL were evaluated by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire, Visual Analogue Scale (VAS) and SF36 ...[more]

PMID: 32958008

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Project description:BackgroundDietary fiber reduces body weight and inflammation in clinical trials. It is unclear whether body mass index (BMI) and inflammation might explain the observed association between higher fiber intake and the lower risk of symptomatic knee osteoarthritis (SXKOA).ObjectivesWe quantified the extent to which BMI and inflammation influenced the relation between dietary fiber and SXKOA.MethodsWe used longitudinal data from the Osteoarthritis Initiative (OAI) and the Framingham Offspring Osteoarthritis Study. At baseline of each study, men and women (mean age: 61 y) with or at risk of knee osteoarthritis were followed for 48 mo in the OAI. Adults (mean age: 53 y) were followed for 9.5 y in the Framingham study. Dietary fiber intake was estimated using a validated food-frequency questionnaire. Measured weight and height were used to calculate BMI. Serum high-sensitivity C-reactive protein (CRP) was measured in the Framingham study only. Incident SXKOA was defined as new onset of a combination of knee pain and radiographic osteoarthritis. We applied marginal structural models to quantify the mediation through BMI in the OAI and the sequential mediation through BMI and CRP in the Framingham study.ResultsIncident SXKOA occurred in 861 knees among 2876 persons in the OAI and in 143 knees among 971 persons in the Framingham study. In persons whose fiber intake was ≥21 g/d compared with those with intakes <21 g/d, the OR (95% CI) was 0.70 (0.53, 0.91) for the overall association with SXKOA and was 0.93 (0.92, 0.95) for the mediation via BMI (per kg/m2) in the OAI. In the Framingham study, the overall association was 0.57 (0.30, 1.09), the mediation through BMI (via BMI and the influence of BMI on CRP) was 0.94 (0.85, 1.02), and the mediation through CRP (per milligram per liter) was 0.99 (0.84, 1.19).ConclusionOur findings suggest that the inverse association of fiber intake and the risk of incident symptomatic knee osteoarthritis is partially mediated by BMI.

Dataset Information

Dietary inflammatory index is associated with pain intensity and some components of quality of life in patients with knee osteoarthritis.

Publications

Dietary inflammatory index is associated with pain intensity and some components of quality of life in patients with knee osteoarthritis.

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