Ontology highlight
ABSTRACT:
SUBMITTER: Mayer K
PROVIDER: S-EPMC4661895 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Mayer Klaus K Baumann Anna-Lena AL Grote Michael M Seeber Stefan S Kettenberger Hubert H Breuer Sebastian S Killian Tobias T Schäfer Wolfgang W Brinkmann Ulrich U
International journal of molecular sciences 20151117 11
TriFabs are IgG-shaped bispecific antibodies (bsAbs) composed of two regular Fab arms fused via flexible linker peptides to one asymmetric third Fab-sized binding module. This third module replaces the IgG Fc region and is composed of the variable region of the heavy chain (VH) fused to CH3 with "knob"-mutations, and the variable region of the light chain (VL) fused to CH3 with matching "holes". The hinge region does not contain disulfides to facilitate antigen access to the third binding site. ...[more]