Ontology highlight
ABSTRACT:
SUBMITTER: Funk N
PROVIDER: S-EPMC6418296 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Funk Natalja N Munz Marita M Ott Thomas T Brockmann Kathrin K Wenninger-Weinzierl Andrea A Kühn Ralf R Vogt-Weisenhorn Daniela D Giesert Florian F Wurst Wolfgang W Gasser Thomas T Biskup Saskia S
Scientific reports 20190314 1
Mutations within Leucine-rich repeat kinase 2 (LRRK2) are associated with late-onset Parkinson's disease. The physiological function of LRRK2 and molecular mechanism underlying the pathogenic role of LRRK2 mutations remain uncertain. Here, we investigated the role of LRRK2 in intracellular signal transduction. We find that deficiency of Lrrk2 in rodents affects insulin-dependent translocation of glucose transporter type 4 (GLUT4). This deficit is restored during aging by prolonged insulin-depend ...[more]