Ontology highlight
ABSTRACT:
SUBMITTER: Di Martino MT
PROVIDER: S-EPMC4662480 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Di Martino Maria Teresa MT Guzzi Pietro Hiram PH Caracciolo Daniele D Agnelli Luca L Neri Antonino A Walker Brian A BA Morgan Gareth J GJ Cannataro Mario M Tassone Pierfrancesco P Tagliaferri Pierosandro P
Oncotarget 20150801 22
Multiple Myeloma (MM) is a malignancy characterized by the hyperdiploid (HD-MM) and the non-hyperdiploid (nHD-MM) subtypes. To shed light within the molecular architecture of these subtypes, we used a novel integromics approach. By annotated MM patient mRNA/microRNA (miRNA) datasets, we investigated mRNAs and miRNAs profiles with relation to changes in transcriptional regulators expression. We found that HD-MM displays specific gene and miRNA expression profiles, involving the Signal Transducer ...[more]