Ontology highlight
ABSTRACT:
SUBMITTER: Rossi M
PROVIDER: S-EPMC4690997 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Rossi Marco M Tagliaferri Pierosandro P Tassone Pierfrancesco P
Annals of translational medicine 20151201 21
MicroRNAs (miRNAs) are short non coding RNAs aberrantly expressed in solid and hematopoietic malignancies where they play a pivotal function as post-transcriptional regulators of gene expression. Recent reports have unveiled a central role of miRNAs in multiple myeloma onset and progression and preclinical findings are progressively disclosing their potential therapeutic value as drugs or targets. In this review, we provide the basic insights of miRNA biology and function, showing how these mole ...[more]