Ontology highlight
ABSTRACT:
SUBMITTER: Peterson LJ
PROVIDER: S-EPMC4662568 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Advanced synthesis & catalysis 20150714 10
Modified reaction conditions that facilitate Pd-catalyzed alkene carboamination reactions of electron-deficient nitrogen nucleophiles are reported. Pent-4-enylamine derivatives bearing <i>N</i>-tosyl or <i>N</i>-trifluoroacetyl groups are coupled with aryl triflates to afford substituted pyrrolidines in good yield. These reactions proceed via a mechanism involving <i>anti</i>-aminopalladation of the alkene, which differs from previously reported analogous reactions of <i>N</i>-aryl and <i>N</i>- ...[more]