Ontology highlight
ABSTRACT:
SUBMITTER: Do JS
PROVIDER: S-EPMC4662649 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Do J-S JS Visperas A A Sanogo Y O YO Bechtel J J JJ Dvorina N N Kim S S Jang E E Stohlman S A SA Shen B B Fairchild R L RL Baldwin W M WM Vignali D A A DA Min B B
Mucosal immunology 20150527 1
Foxp3-expressing regulatory T cells (Tregs) are central regulators of immune homeostasis and tolerance. As it has been suggested that proper Treg function is compromised under inflammatory conditions, seeking for a pathway that enhances or stabilizes Treg function is a subject of considerable interest. We report that interleukin (IL)-27, an IL-12 family cytokine known to have both pro- and anti-inflammatory roles in T cells, plays a pivotal role in enhancing Treg function to control T cell-induc ...[more]