Drug target prioritization by perturbed gene expression and network information.
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ABSTRACT:
SUBMITTER: Isik Z
PROVIDER: S-EPMC4663505 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Publications
Drug target prioritization by perturbed gene expression and network information.
Isik Zerrin Z Baldow Christoph C Cannistraci Carlo Vittorio CV Schroeder Michael M
Scientific reports 20151130
Drugs bind to their target proteins, which interact with downstream effectors and ultimately perturb the transcriptome of a cancer cell. These perturbations reveal information about their source, i.e., drugs' targets. Here, we investigate whether these perturbations and protein interaction networks can uncover drug targets and key pathways. We performed the first systematic analysis of over 500 drugs from the Connectivity Map. First, we show that the gene expression of drug targets is usually no ...[more]
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