Ontology highlight
ABSTRACT:
SUBMITTER: Maute RL
PROVIDER: S-EPMC4664306 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Maute Roy L RL Gordon Sydney R SR Mayer Aaron T AT McCracken Melissa N MN Natarajan Arutselvan A Ring Nan Guo NG Kimura Richard R Tsai Jonathan M JM Manglik Aashish A Kruse Andrew C AC Gambhir Sanjiv S SS Weissman Irving L IL Ring Aaron M AM
Proceedings of the National Academy of Sciences of the United States of America 20151110 47
Signaling through the immune checkpoint programmed cell death protein-1 (PD-1) enables tumor progression by dampening antitumor immune responses. Therapeutic blockade of the signaling axis between PD-1 and its ligand programmed cell death ligand-1 (PD-L1) with monoclonal antibodies has shown remarkable clinical success in the treatment of cancer. However, antibodies have inherent limitations that can curtail their efficacy in this setting, including poor tissue/tumor penetrance and detrimental F ...[more]