An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy.
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ABSTRACT:
SUBMITTER: Tavare R
PROVIDER: S-EPMC4703530 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy.
Tavaré Richard R Escuin-Ordinas Helena H Mok Stephen S McCracken Melissa N MN Zettlitz Kirstin A KA Salazar Felix B FB Witte Owen N ON Ribas Antoni A Wu Anna M AM
Cancer research 20151116 1
The rapidly advancing field of cancer immunotherapy is currently limited by the scarcity of noninvasive and quantitative technologies capable of monitoring the presence and abundance of CD8(+) T cells and other immune cell subsets. In this study, we describe the generation of (89)Zr-desferrioxamine-labeled anti-CD8 cys-diabody ((89)Zr-malDFO-169 cDb) for noninvasive immuno-PET tracking of endogenous CD8(+) T cells. We demonstrate that anti-CD8 immuno-PET is a sensitive tool for detecting changes ...[more]
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