Ontology highlight
ABSTRACT:
SUBMITTER: Richard AS
PROVIDER: S-EPMC4664333 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Richard Audrey Stéphanie AS Zhang Adam A Park Sun-Jin SJ Farzan Michael M Zong Min M Choe Hyeryun H
Proceedings of the National Academy of Sciences of the United States of America 20151102 47
Phosphatidylserine (PS) receptors contribute to two crucial biological processes: apoptotic clearance and entry of many enveloped viruses. In both cases, they recognize PS exposed on the plasma membrane. Here we demonstrate that phosphatidylethanolamine (PE) is also a ligand for PS receptors and that this phospholipid mediates phagocytosis and viral entry. We show that a subset of PS receptors, including T-cell immunoglobulin (Ig) mucin domain protein 1 (TIM1), efficiently bind PE. We further sh ...[more]