Ontology highlight
ABSTRACT:
SUBMITTER: Braun NJ
PROVIDER: S-EPMC7497253 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Braun Niklas J NJ Quek Jun P JP Huber Simon S Kouretova Jenny J Rogge Dorothee D Lang-Henkel Heike H Cheong Ezekiel Z K EZK Chew Bing L A BLA Heine Andreas A Luo Dahai D Steinmetzer Torsten T
ChemMedChem 20200630 15
A series of cyclic active-site-directed inhibitors of the NS2B-NS3 proteases from Zika (ZIKV), West Nile (WNV), and dengue-4 (DENV4) viruses has been designed. The most potent compounds contain a reversely incorporated d-lysine residue in the P1 position. Its side chain is connected to the P2 backbone, its α-amino group is converted into a guanidine to interact with the conserved Asp129 side chain in the S1 pocket, and its C terminus is connected to the P3 residue via different linker segments. ...[more]