Ontology highlight
ABSTRACT:
SUBMITTER: Lu M
PROVIDER: S-EPMC4664340 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Lu Manman M Hou Guangjin G Zhang Huilan H Suiter Christopher L CL Ahn Jinwoo J Byeon In-Ja L IJ Perilla Juan R JR Langmead Christopher J CJ Hung Ivan I Gor'kov Peter L PL Gan Zhehong Z Brey William W Aiken Christopher C Zhang Peijun P Schulten Klaus K Gronenborn Angela M AM Polenova Tatyana T
Proceedings of the National Academy of Sciences of the United States of America 20151109 47
Host factor protein Cyclophilin A (CypA) regulates HIV-1 viral infectivity through direct interactions with the viral capsid, by an unknown mechanism. CypA can either promote or inhibit viral infection, depending on host cell type and HIV-1 capsid (CA) protein sequence. We have examined the role of conformational dynamics on the nanosecond to millisecond timescale in HIV-1 CA assemblies in the escape from CypA dependence, by magic-angle spinning (MAS) NMR and molecular dynamics (MD). Through the ...[more]