Ontology highlight
ABSTRACT:
SUBMITTER: Liu C
PROVIDER: S-EPMC4785225 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Nature communications 20160304
The host cell factor cyclophilin A (CypA) interacts directly with the HIV-1 capsid and regulates viral infectivity. Although the crystal structure of CypA in complex with the N-terminal domain of the HIV-1 capsid protein (CA) has been known for nearly two decades, how CypA interacts with the viral capsid and modulates HIV-1 infectivity remains unclear. We determined the cryoEM structure of CypA in complex with the assembled HIV-1 capsid at 8-Å resolution. The structure exhibits a distinct CypA-b ...[more]