Ontology highlight
ABSTRACT:
SUBMITTER: Jain AK
PROVIDER: S-EPMC4664533 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
International journal of nanomedicine 20151124
We report the formulation of novel composite nanoparticles that combine the high transfection efficiency of cationic peptide-DNA nanoparticles with the biocompatibility and prolonged delivery of polylactic acid-polyethylene glycol (PLA-PEG). The cationic cell-penetrating peptide RALA was used to condense DNA into nanoparticles that were encapsulated within a range of PLA-PEG copolymers. The composite nanoparticles produced exhibited excellent physicochemical properties including size <200 nm and ...[more]