Ontology highlight
ABSTRACT:
SUBMITTER: Misra A
PROVIDER: S-EPMC4664754 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Misra Ashish A Ou Jianhong J Zhu Lihua Julie LJ Green Michael R MR
Genomics data 20151003
Alternative splicing is a key mechanism for generating proteome diversity, however the mechanisms regulating alternative splicing are poorly understood. Using a genome-wide RNA interference screening strategy, we identified cleavage and polyadenylation specificity factor (CPSF) and symplekin (SYMPK) as cofactors of the well-known splicing regulator RBFOX2. To determine the role of CPSF in alternative splicing on a genome-wide level, we performed paired-end RNA sequencing (RNA-seq) to compare spl ...[more]