Ontology highlight
ABSTRACT:
SUBMITTER: Monin L
PROVIDER: S-EPMC4665786 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Monin Leticia L Griffiths Kristin L KL Lam Wing Y WY Gopal Radha R Kang Dongwan D DD Ahmed Mushtaq M Rajamanickam Anuradha A Cruz-Lagunas Alfredo A Zúñiga Joaquín J Babu Subash S Kolls Jay K JK Mitreva Makedonka M Rosa Bruce A BA Ramos-Payan Rosalio R Morrison Thomas E TE Murray Peter J PJ Rangel-Moreno Javier J Pearce Edward J EJ Khader Shabaana A SA
The Journal of clinical investigation 20151116 12
Parasitic helminth worms, such as Schistosoma mansoni, are endemic in regions with a high prevalence of tuberculosis (TB) among the population. Human studies suggest that helminth coinfections contribute to increased TB susceptibility and increased rates of TB reactivation. Prevailing models suggest that T helper type 2 (Th2) responses induced by helminth infection impair Th1 immune responses and thereby limit Mycobacterium tuberculosis (Mtb) control. Using a pulmonary mouse model of Mtb infecti ...[more]