Ontology highlight
ABSTRACT:
SUBMITTER: Zhao W
PROVIDER: S-EPMC5873221 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Zhao Weiheng W Xiao Shuxiu S Li Hongjin H Zheng Tingting T Huang Jian J Hu Ran R Zhang Baohua B Liu Xinguang X Huang Gonghua G
Frontiers in immunology 20180321
Persistent activation of mitogen-activated protein kinase (MAPK) is believed to be involved in psoriasis pathogenesis. MAPK phosphatase-1 (MKP-1) is an important negative regulator of MAPK activity, but the cellular and molecular mechanisms of MKP-1 in psoriasis development are largely unknown. In this study, we found that the expression of MKP-1 was decreased in the imiquimod (IMQ)-induced psoriasiform mouse skin. MKP-1-deficient (MKP-1<sup>-/-</sup>) mice were highly susceptible to IMQ-induced ...[more]