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A novel self-assembled sandwich nanomedicine for NIR-responsive release of NO.

ABSTRACT: A novel sandwich nanomedicine (GO-BNN6) for near-infrared (NIR) light responsive release of nitric oxide (NO) has been constructed by self-assembly of graphene oxide (GO) nanosheets and a NO donor BNN6 through the ?-? stacking interaction. The GO-BNN6 nanomedicine has an extraordinarily high drug loading capacity (1.2 mg BNN6 per mg GO), good thermal stability, and high NIR responsiveness. The NO release from GO-BNN6 can be easily triggered and effectively controlled by adjusting the switching, irradiation time and power density of NIR laser. The intracellular NIR-responsive release of NO from the GO-BNN6 nanomedicine causes a remarkable anti-cancer effect.

SUBMITTER: Fan J

PROVIDER: S-EPMC4666708 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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A novel self-assembled sandwich nanomedicine for NIR-responsive release of NO.

Fan Jing J He Nongyue N He Qianjun Q Liu Yi Y Ma Ying Y Fu Xiao X Liu Yijing Y Huang Peng P Chen Xiaoyuan X

Nanoscale 20151116 47

A novel sandwich nanomedicine (GO-BNN6) for near-infrared (NIR) light responsive release of nitric oxide (NO) has been constructed by self-assembly of graphene oxide (GO) nanosheets and a NO donor BNN6 through the π-π stacking interaction. The GO-BNN6 nanomedicine has an extraordinarily high drug loading capacity (1.2 mg BNN6 per mg GO), good thermal stability, and high NIR responsiveness. The NO release from GO-BNN6 can be easily triggered and effectively controlled by adjusting the switching, ...[more]

PMID: 26568270

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