Ontology highlight
ABSTRACT:
SUBMITTER: Cuadrado E
PROVIDER: S-EPMC4667845 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Cuadrado Eloy E Booiman Thijs T van Hamme John L JL Jansen Machiel H MH van Dort Karel A KA Vanderver Adeline A Rice Gillian I GI Crow Yanick J YJ Kootstra Neeltje A NA Kuijpers Taco W TW
PloS one 20151202 12
Unlike resting CD4+ T cells, activated CD4+T cells are highly susceptible to infection of human immunodeficiency virus 1 (HIV-1). HIV-1 infects T cells and macrophages without activating the nucleic acid sensors and the anti-viral type I interferon response. Adenosine deaminase acting on RNA 1 (ADAR1) is an RNA editing enzyme that displays antiviral activity against several RNA viruses. Mutations in ADAR1 cause the autoimmune disorder Aicardi-Goutieères syndrome (AGS). This disease is characteri ...[more]