Ontology highlight
ABSTRACT:
SUBMITTER: Sun Y
PROVIDER: S-EPMC4669440 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Sun Yao Y Weng Yuteng Y Zhang Chenyang C Liu Yi Y Kang Chen C Liu Zhongshuang Z Jing Bo B Zhang Qi Q Wang Zuolin Z
Scientific reports 20151204
Proteoglycans play important roles in regulating osteogenesis. Dentin matrix protein 1 (DMP1) is a highly expressed bone extracellular matrix protein that regulates both bone development and phosphate metabolism. After glycosylation, an N-terminal fragment of DMP1 protein was identified as a new proteoglycan (DMP1-PG) in bone matrix. In vitro investigations showed that Ser(89) is the key glycosylation site in mouse DMP1. However, the specific role of DMP1 glycosylation is still not understood. I ...[more]