Ontology highlight
ABSTRACT:
SUBMITTER: Ottina E
PROVIDER: S-EPMC4669773 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Cell death & disease 20150122
Tumor necrosis factor (TNF) is a key signaling molecule orchestrating immune and inflammatory responses and possesses the capacity to trigger apoptotic as well as necroptotic cell death. Apoptotic cell death elicited by TNF has been demonstrated to engage pro-apoptotic Bcl-2 family proteins, most prominently the BH3-only protein Bid, a key substrate of caspase-8, the key effector protease downstream of TNF receptor I. Most recently, the BH3 domain-containing protein Bad (Bcl-2-antagonist of cell ...[more]