Ontology highlight
ABSTRACT:
SUBMITTER: Ljubicic S
PROVIDER: S-EPMC4991214 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Cell reports 20150129 4
Strategies that simultaneously enhance the survival and glucose responsiveness of insulin-producing β cells will greatly augment β cell replacement therapies in type 1 diabetes (T1D). We show that genetic and pharmacologic mimetics of the phosphorylated BCL-2 homology 3 (BH3) domain of BAD impart β-cell-autonomous protective effects in the face of stress stimuli relevant to β cell demise in T1D. Importantly, these benefits translate into improved engraftment of donor islets in transplanted diabe ...[more]