Ontology highlight
ABSTRACT:
SUBMITTER: Davidson JO
PROVIDER: S-EPMC4671127 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Davidson Joanne O JO Rout Alexandra L AL Wassink Guido G Yuill Caroline A CA Zhang Frank G FG Green Colin R CR Bennet Laura L Gunn Alistair J AJ
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20150715 12
Hypothermia is partially neuroprotective after neonatal hypoxic-ischemic encephalopathy. Blockade of connexin hemichannels can improve recovery of brain activity and cell survival after ischemia in near-term fetal sheep. In this study, we investigated whether combining delayed hypothermia with connexin hemichannel blockade with intracerebroventricular infusion of a mimetic peptide can further improve outcomes after cerebral ischemia. Fetal sheep (0.85 gestation) received 30 minutes of cerebral i ...[more]