Ontology highlight
ABSTRACT:
SUBMITTER: Zhu B
PROVIDER: S-EPMC4671835 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Molecular cell 20151121 5
A central mechanism for controlling circadian gene amplitude remains elusive. We present evidence for a "facilitated repression (FR)" model that functions as an amplitude rheostat for circadian gene oscillation. We demonstrate that ROR and/or BMAL1 promote global chromatin decondensation during the activation phase of the circadian cycle to actively facilitate REV-ERB loading for repression of circadian gene expression. Mechanistically, we found that SRC-2 dictates global circadian chromatin rem ...[more]