Ontology highlight
ABSTRACT:
SUBMITTER: Zhao X
PROVIDER: S-EPMC4912445 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Zhao Xuan X Hirota Tsuyoshi T Han Xuemei X Cho Han H Chong Ling-Wa LW Lamia Katja K Liu Sihao S Atkins Annette R AR Banayo Ester E Liddle Christopher C Yu Ruth T RT Yates John R JR Kay Steve A SA Downes Michael M Evans Ronald M RM
Cell 20160526 7
Defects in circadian rhythm influence physiology and behavior with implications for the treatment of sleep disorders, metabolic disease, and cancer. Although core regulatory components of clock rhythmicity have been defined, insight into the mechanisms underpinning amplitude is limited. Here, we show that REV-ERBα, a core inhibitory component of clock transcription, is targeted for ubiquitination and subsequent degradation by the F-box protein FBXW7. By relieving REV-ERBα-dependent repression, F ...[more]