Ontology highlight
ABSTRACT:
SUBMITTER: Pandurangan AP
PROVIDER: S-EPMC4671957 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Pandurangan Arun Prasad AP Vasishtan Daven D Alber Frank F Topf Maya M
Structure (London, England : 1993) 20151119 12
We have developed a genetic algorithm for building macromolecular complexes using only a 3D-electron microscopy density map and the atomic structures of the relevant components. For efficient sampling the method uses map feature points calculated by vector quantization. The fitness function combines a mutual information score that quantifies the goodness of fit with a penalty score that helps to avoid clashes between components. Testing the method on ten assemblies (containing 3-8 protein compon ...[more]