Ontology highlight
ABSTRACT:
SUBMITTER: Jolley CC
PROVIDER: S-EPMC2242741 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Jolley Craig C CC Wells Stephen A SA Fromme Petra P Thorpe M F MF
Biophysical journal 20071109 5
Recent experimental advances in producing density maps from cryo-electron microscopy (cryo-EM) have challenged theorists to develop improved techniques to provide structural models that are consistent with the data and that preserve all the local stereochemistry associated with the biomolecule. We develop a new technique that maintains the local geometry and chemistry at each stage of the fitting procedure. A geometric simulation is used to drive the structure from some appropriate starting poin ...[more]