Ontology highlight
ABSTRACT:
SUBMITTER: Madu IG
PROVIDER: S-EPMC4672295 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Madu Ikenna G IG Li Shirley S Li Baozong B Li Haitang H Chang Tammy T Li Yi-Jia YJ Vega Ramir R Rossi John J Yee Jiing-Kuan JK Zaia John J Chen Yuan Y
Scientific reports 20151208
We have recently identified a chemotype of small ubiquitin-like modifier (SUMO)-specific protease (SENP) inhibitors. Prior to the discovery of their SENP inhibitory activity, these compounds were found to inhibit HIV replication, but with an unknown mechanism. In this study, we investigated the mechanism of how these compounds inhibit HIV-1. We found that they do not affect HIV-1 viral production, but significantly inhibited the infectivity of the virus. Interestingly, virions produced from cell ...[more]