Parkin structure and function.
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ABSTRACT:
SUBMITTER: Seirafi M
PROVIDER: S-EPMC4672691 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Parkin structure and function.
Seirafi Marjan M Kozlov Guennadi G Gehring Kalle K
The FEBS journal 20150316 11
Mutations in the parkin or PINK1 genes are the leading cause of the autosomal recessive form of Parkinson's disease. The gene products, the E3 ubiquitin ligase parkin and the serine/threonine kinase PINK1, are neuroprotective proteins, which act together in a mitochondrial quality control pathway. Here, we review the structure of parkin and mechanisms of its autoinhibition and function as a ubiquitin ligase. We present a model for the recruitment and activation of parkin as a key regulatory step ...[more]
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